분야
pptxHistory
A 55-year-old woman presents to the hospital with cellulitis. She reports a history of urticaria 30 years earlier associated with taking penicillin for a respiratory tract infection.
Should cephalosporins be avoided? More generally, how should patients with a history of allergy to antibiotics be evaluated and treated?
Allergy is associated with substantial morbidity and mortality and increased health care costs.
Any organ may be affected, but the skin is most commonly involved.
Data from the Boston Collaborative Drug Surveillance Program
2.2 percent frequency of cutaneous drug reactions among hospitalized patients
Antibiotics
amoxicillin
trimethoprim–sulfamethoxazole
Ampicillin
six-month prospective analysis in France
cutaneous drug eruptions : 3.6 per 1000 hospitalized patients
antibiotics accounted for 55 percent of cases.
