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의대 본과 4학년 PK과제 Immunoglobulin Einhealthanddisease에 대한 자료입니다.
본문내용
Immunoglobulin E
in health and disease
Basic characteristics of IgE
IgE is the antibody isotype that contains the ε heavy chain and it is a monomer with five domains in the immunoglobulin structure
in plasma
- concentration of less than 1 μg/mL
in serum
- a half-life of about 2 days
Basic characteristics of IgE
IgE binds to its receptor FcεR,
High-affinity receptors (FcεRI)
-wide variety of cells; mast cells, basophils, antigen presenting cells, monocytes and platelets
low-affinity receptors (FcεRII)
- B-cells, monocytes and dendritic cells
Role of IgE in health & disease
IgE was discovered for its involvement in allergic reactions (Type I hypersensitivities)
People, who have a tendency to develop symptoms when exposed to allergens, produce IgE specific to that allergen, which evokes a cascade of reactions
dominant role of IgE is to protect the host from parasitic infections, specially helminth infections
참고문헌
References
Immunoglobulin E in health and disease
- M. Amarasekera, Department of Physiology,
Faculty of Medicine, University of Kelaniya,
Ragama 11010, Sri Lanka doi: 10. 5415/apallergy.
2011.1.1.12 Asia Pac Allergy 2011;1:12-15