소개글
[생화학] 암을위한 진단과 치료도구로써의 렉틴의 사용에 대한 자료입니다.
목차
Introduction
-Defintion and Biochemistry of Lectins
-Lectin -Glycoconjugate Interactoin
Use of Lectins
-Lectin as Diagnostic Probes
-Lectin as Tumor -Specific Surface Marker
-Lectin as Antitumor Cytotoxins
-Lectin as Immunotoxins
-Lectin as Biological response modifiers
-Lectin as Carrier in Targeted Therapy
-Lectin as Adhesion Molecules
Future scope of Lectin
-Glycoconjugate Study in Diagnosis and Therapy of cancer
본문내용
Definition and Biochemistry
of Lectins
Structure : Origin protein + 탄수화물 (ligand)
· Sources of lectins : Animals, plants, bacteria
· Grouping ; by their preferential binding to the type
D-pyranose sugars
by dependent ; C-type or S-type
Lectin as Diagnostic Probes
Binding specificities
Ex ) Covavlin A(Con A) – Glucose mannose α form (binding)
β form (non - bindding)
Experimental method
Lectin – affinity eletrophoresis
Lectin – affinity chromatography
NMR chromatograpy
참고문헌
ELSEVIER; REVIEW
;Rustom Mody, Shantaram Joshi, and William Chaney