소개글
[논문발표 PPT] RhoA Prenylation Inhibitor Produces Relaxation of Tonic Smooth Muscle of Internal Anal Sphincter에 대한 자료입니다.
본문내용
The purpose of the present study was to determine the role of RhoA prenylation in the activation of RhoA and in the maintenanace of the basal and stimulated (by U-46619) state, before and after prenylation inhibitor GGTI-297.
We also determined cellular distribution of RhoA and ROCK activity. For comparison, we used phasic rectal smooth muscle (RSM).
GGTaseI (=prenyltransferase) : Catalyzes the covalent attachment of the geranylgeranyl group from GGPP to RhoA(prenylation)
GGTI-297 (=Rho A Prenylation Inhibitor) : Blocks RhoA prenylation via inhibiting transfer of geranylgeranyl group to RhoA via inhibition of GGTaseI
RhoA prenylation : Translocation of RhoA to the membrane followed by the activation of RhoA/ROCK
참고문헌
RhoA Prenylation Inhibitor Produces Relaxation of Tonic Smooth Muscle of Internal Anal Sphincter
(Chirag A. Patel and Satish Rattan)
-Journal of Pharmacology and Experimental Therapeutics Vol. 321, No.2, 2007
하고 싶은 말
대학원 석사과정 때 위 논문을 읽고 발표한 PPT입니다.
PPT에 발표 스크립트도 포함되어 있습니다.
논문읽고 발표수업 하실 때 참고하시면 많은 도움 되실겁니다.