소개글
[논문발표PPT] RhoA –and PKC-α-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells에 대한 자료입니다.
본문내용
We have shown that in colonic smooth muscle, PKC-α and RhoA translocate and associate with each other in the particulate fraction in response to stimulation with acetylcholine.
We have also shown that RhoA interacts directly with PKC-α in vitro.
1) In human endothelial cells, activation of ROCK by RhoA requires PKC activation .
(1998,Hippenstiel S et al)
2) We have recently shown that preincubation of SMCs with Y-27632(specific ROCKII inhibitor), partially inhibited contraction(~50%) concomitant with inhibition of association of ROCKII with HSP27 in the particulate fraction .(2004,Patil SB, et al)
The aims of the studies were to investigate
the agonist-induced possible association and
translocation of MYPT with HSP27 and to
examine the roles played by RhoA and PKC
pathways in the regulation of MLCP activity.
참고문헌
Am J Physiol Gastrointest Liver Physial Vol. 290, No.G83-G95, 2006
(Suresh B. Patil and Khalil N. Bitar)
하고 싶은 말
대학원 석사과정 때 위 논문을 읽고 발표한 PPT입니다.
PPT에 발표 스크립트도 포함되어 있습니다.
논문읽고 발표수업 하실 때 참고하시면 많은 도움 되실겁니다.