소개글
[생물화학공학]Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes(영문)에 대한 자료입니다.
목차
1.Introduction
2.Ion Binding Response of DNA-SWNT
3.Principle of Fluorescence energy shift
4.Fluorescence 3D profile of a DNA-SWNT solution
5.Application - Ion Binding Response in Mammalian cells
6.Limitation & Comments
7.Reference
본문내용
slightly thinner and elongated than B-DNA conformation.
The conformational change readily occurs in alternating Purine and Pyrimidine sequence.
Z-DNA is a higher energy conformation than B-DNA (ΔG near +4kcal/mol)
The roles of Z – DNA in biologic system are not clearly identified and an area of active study.
A high affinity Z-DNA Binding Protein , DRADA
hollow cylinders consisting of a single sheet of graphite wrapped into a cylinder
The Near-InfraRed (NIR) photoluminescence of semiconducting SWNT
Low autofluorescence in the NIR range
Large Stokes shift between the excitation and emission
Energy shift of SWNT
Generated by using literature value.
Using constant dielectric value in Bethe-salpeter equation generate horizontal line.
Model is able to predict magnitude of the energy shift.
참고문헌
Heller, D. A., Jeng, E.S. et al., Science 311, 508(2006).
A. Rich, J. Biol. Chem. 271, 11595 (1996).
Gao, H., Kong, Y., Annu. Rev. Mater. Res. 34, 123-150(2004).
S. Rothenburg et al., Proc. Natl. Acad. Sci. U.S.A. 102,1602 (2005).
D. A. Heller, S. Baik, T. E. Eurell, M. S. Strano, Adv. Mater. 17, 2793 (2005).
Heller, D. A., Jeng, E.S. et al., Supporting online material for optical detection of DNA conformational polymorphism on single walled carbon nanotubes, Science 311, 508(2006).
Lakowicz, J.R., Principles of Fluorescence Spectroscopy, Plenum Press, New York (1990).