[PBL] AIH(Autoimmune hepatitis)(영문)

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레포트 > 의약계열
2010.08.14
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[PBL] AIH(Autoimmune hepatitis)(영문)에 대한 자료입니다.

-Autoimmune hepatitis

-PATHOGENESIS

-CLASSIFICATION

-CLINICAL CRITERIA

-INDICATIONS

-VARIANT FORMS

-reference

본문내용

Autoimmune hepatitis

Autoimmune hepatitis (AIH) is a disorder of unknown cause characterized by unresolving inflammation of the liver and by the presence of interface hepatitis on histologic examination (Fig. 1-1), hypergammaglobulinemia, and autoantibodies. Diagnosis requires the exclusion of other chronic liver diseases that have similar features, including Wilson disease, chronic viral hepatitis, drug-induced liver disease, nonalcoholic fatty liver disease, and the immune cholangiopathies of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Panacinar or lobular hepatitis is within the histologic spectrum of AIH (Fig. 1-2), and centrilobular (Rappaport zone 3) necrosis has been described in AIH and may indicate an early stage of the disease before the development of interface hepatitis.[2]

Figure 1-1. Histopathology of interface hepatitis. The limiting plate of the portal tract is disrupted by a lymphoplasmacytic infiltrate. This histologic pattern is the hallmark of autoimmune hepatitis, but it is not disease specific. (Hematoxylin and eosin, ×200.)

참고문헌

Feldman: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 9th ed. 1461-1475
해리슨 17판 2370-2372

#AIHAutoimmune #AIH #Autoimmune #PBL #hepatitis

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