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[응용독성학] 위암, 그리고 브로컬리

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레포트 > 자연계열
2010.09.08
30페이지 / ppt
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[응용독성학] 위암, 그리고 브로컬리에 대한 자료입니다.

1. Statistics of cancer
2. Factor that cause stomach cancer
a. Diet
b. Infection
3. Property of H. pylori
4. Mechanism that H. pylori cause stomach cancer
5. Broccoli
6. Sulforaphane
7. Effect of Sulforaphane
8. Other plants contain sulforaphane.
9. Conclusion
10. Reference
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본문내용

Some food make ROS (Inflammation)
Nitrate-rich food
High salt diet
Spicy food
Fatty food
Alcohol
Some food make Benzo(a)pyrene
Smoked food
Broiled food

Barry J Marshall reveals the relation of H. pylori to gastric adenocarcinoma and lymphoma.
The relation of Helicobacter pylori to gastric adenocarcinoma
and lymphoma, Marshall BJ, Windsor HM 1984
Nobel prize in physiology or medicine on 2005
H. pylori infection may be the most common chronic bacterial infection which causes inflammation.
Though it has a lots of debates, but many people agree to that relation.
negative H. Pylori status is associated with poor prognosis
in patient with gastric cancer 2009

Nutrition Value:
It contains and rich in dietary fiber, provitamin A carotenoids, Folic Acid, Calcium, Iron, vitamin C and vitamin K. Isothiocyanates are a class of compounds recently identified key to the anticancer properties of cruciferous vegetables, most active isothiocyanate is sulfor-aphane.
Dosage: 500 to 2000mgs daily in divided oral dose.
Sprouts contain 20 to 50 times more sulforaphane in much greater quantity than mature broccoli.
Boiling reduce the levels of anti-cancer compounds in broccoli
Safety - No toxic data available, generally considered safe for appications and as vegetables

참고문헌

1. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyreneinduced stomach tumors, 2005 Paul Talalay
2. Glucosinolate research in the Arabidopsis era 10 May 2002
3. 보건복지부- 2007 07 20 암 발생률-생존율 통계
4. The relation of Helicobacter pylori to gastric adenocarcinoma and lymphoma ,Barry J. Marshall 1984
5. Human gastric carcinogenesis, Pelayo Correa, Cancer research, 1992
6. Percentages are relative to US recommendations for adults.
Source: USDA Nutrient database
7. Glucosinolate research in the Arabidopsis era, Ute Wittstock and Barbara A.Halkier
8. Cancer Chemopreventive Potential of Sulforamate, sulforaphane That Induces Phase 2 Drug-metabolizing Enzymes1 1997

9. Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization (carcinogenesis, 2004, SJT Jackson
10. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates (1994, pnas Y Zhang)
11. Effect of broccoli and its phytochemical sulforaphane in balanced diets on the detoxification enzymes levels of tilapia (Oreochromis niloticus) exposed to a carcinogenic and ,
12. mutagenic pollutant. (2009, V. Villa-Cruz chemosphere)
13. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure

#브로컬리 #응용독성학 #독성학 #응용 #위암

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