소개글
[약리학] 아스피린의 항암제 효과(영문)에 대한 자료입니다.
목차
Anticancer effect of Aspirin
Mechanism of action
Anticancer effect
Experiment
Further study
본문내용
Recent studies have demonstrated that cyclooxygenase-2 (COX-2) expression is up-regulated in a number of cancers.
The COX-2 isoform is induced in response to inflammatory factors and is expressed in premalignant lesions, including cervical tissues.
In this preliminary study, the variability of COX-2 overexpression in cervical premalignant lesions was assessed.
NSAIDs and COX-2 inhibitors show anti-cancer activities in many cancer cells.
Aspirin showed strongest inhibitory effects on viability and survival of YD-8 cells.
Aspirin treatment resulted in severe cell shrinkage and nuclear DNA fragmentation in YD-8 cells.