분야
pptx2.Principles
3.Experimental results
4.Future trends & Advantages
5.Limitation & Breakthrough
6.References
Have applications in nanorobotics
Twisting motion
Any molecule composed entirely of carbon
Form of a hollow sphere, ellipsoid, or tube
Has unique chemistry
Contraction and Relaxation in different pH condition with “in-vivo”
Degradation by temperature change (Low thermal stability)
Low durability to repeated stimulations (Probability to denature)
Result: Average cycling efficiency is nearly 100% over 10 cycles
Meaning: Highly reversible conformational transition is expected
Presence of the fullerenes actually improved the cycling efficiency !
Aggregation problem
Each unit is small (DNA size) Lots of hybrids in a system coordination may be difficult
Limitations when applied in vivo
Electricity supply is required (external stimulus)
Should be attached near the system for pH control
Should be recharged from time to time
Fullerene toxicity
Hybrids can be dissociated in vivo the dissociated fullerenes can peroxide lipids of specific cells and destroy them
[2] Su Ryon Shin, Kyeong Sik Jin, Chang Kee Lee, Sun I. Kim, Geoffrey M. Spinks, Insuk So, Ju-Hong Jeon, Tong Mook Kang, Ji Young Mun, Sung-Sik Han, Moonhor Ree, and Seon Jeong Kim, Fullerene Attachment Enhances Performance of a DNA Nanomachine, Adv. Mater., 2009, 1907, 1910
[3] Kyeong Sik Jin, Su Ryon Shin, Byungcheol Ahn, Yecheol Rho, Seon Jeong Kim, and Moonhor Ree, pH-Dependent Structures of an i-Motif DNA in Solution, J. Phys. Chem. B, 2009, 113, 1852–1856
[4] Souvik Modi, Swetha M. G., Debanjan Goswami, Gagan D. Gupta, Satyajit Mayor and Yamuna Krishnan, A DNA nanomachine that maps spatial and temporal pH changes inside living cells, NATURE NANOTECHNOLOGY, May 2009, Vol 4, 325-330
[5] Yinghua Peng, Xiaohui Wang, Yi Xiao, Lingyan Feng, Chao Zhao, Jinsong Ren and Xiaogang Qu, i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon Nanotube, J. Am. Chem. Soc., 2009, 131 (38), pp 13813–13818
[6] Dongsheng Liu and Shankar Balasubramanian, A Proton-Fuelled DNA Nanomachine, Angew. Chem. Int. Ed. 2003, 42, 5734 –5736
[7] http://en.wikipedia.org/wiki/Fullerene
[8] http://news.donga.com/3/all/20110426/36692154/1
[9] http://www.donga.com/fbin/output?n=200903130056
[10] http://www.answers.com/topic/dna-nanotechnology
[11] Picture of fullerene: http://en.wikipedia.org/wiki/File:C60a.png
[12] Picture of DNA: http://biopedia.org/index.php/File:DNA_Overview.png
[13] Mechanism: http://blog.naver.com/ksleens?Redirect=Log&logNo=40104777766
[14] Picture of artificial muscle
http://eap.jpl.nasa.gov/
[15]Picture of muscle transplant
http://blog.paran.com/blog/list/listBoard.kth?pmcId=ninuko
[16] Picture of wearable muscle
http://rano.tistory.com/30
[17] Picture of artificial heart
http://dvice.com/archives/2010/03/turn-yourself-i.php
