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분야
ppt1.What is nano technology?
2.History of nano technology
3.State of the diagnosis technology
4.Contacting pattern
5.Kinetics / Performance equation
6.Economic / Socio-cultural impact
7.Conclusion
~ 1000 Years Ago (Middle Ages) – Gold nanoparticles of different sizes used to produce different colors in stained glass windows
1959 – “There is plenty of room at the bottom” by R. Feynman
1974 – “Nanotechnology” - Taniguchi uses the term nanotechnology for the first time
1981 – IBM develops Scanning Tunneling Microscope
1985 – “Buckyball” - Scientists at Rice University and University of Sussex discover C60
1986 – “Engines of Creation” - First book on nanotechnology by K. Eric Drexler. Atomic Force Microscope invented by Binnig, Quate and Gerbe
1989 – IBM logo made with individual atoms
1991 – Carbon nanotube discovered by S. Iijima
1999 – “Nanomedicine” – 1st nanomedicine book by R. Freitas
2000 – “National Nanotechnology Initiative” launched
Nanotechnology offers tools and techniques for more effective detection, diagnosis and treatment of diseases
Detection and Diagnosis
Lab on chips help detection and diagnosis of diseases more efficiently
Nanowire and cantilever lab on chips help in early detection of cancer biomarkers
Receptor-mediated endocytosis of the nanocarrier(1)
Exocytosis of the nanocarrier(1a)
Dissociation, acidification, release of the drug into the brain; (1b)
Recycling of receptors(1c and 1d)
Adsorptive-mediated endocytosis (2a)
Exocytosis of positively charged nanocarriers.(2b)
R3 : The reaction rate for direct hybridization,
F3 : the flux of bulk-phase target molecules that collide with the surface,
Pp : multiplied by the probability that the collision location is a probe site,
Pa : the probability that that probe is available for hybridization, (i.e., it has not yet undergone hybridization with another target),
Pr : the probability that the collision will result in successful hybridization,
K Pappaert, P Van Hummelen - Chemical engineering , 2003 – Elsevier
D Erickson - Analytical biochemistry, 2003 – Elsevier
http://www.particleandfibretoxicology.com/
http://nano.cancer.gov/learn/understanding/video_journey.asp
http://www.immortalhumans.com/nanomedicine-%E2%80%93-dechronification-treating-the-disease-of-natural-death-part-2/
