![[분자생물학] G-CSF-1](http://images.happyhaksul.com/thumb/723/722531-0001.gif)
![[분자생물학] G-CSF-2](http://images.happyhaksul.com/thumb/723/722531-0002.gif)
![[분자생물학] G-CSF-3](http://images.happyhaksul.com/thumb/723/722531-0003.gif)
![[분자생물학] G-CSF-4](http://images.happyhaksul.com/thumb/723/722531-0004.gif)
![[분자생물학] G-CSF-5](http://images.happyhaksul.com/thumb/723/722531-0005.gif)
![[분자생물학] G-CSF-6](http://images.happyhaksul.com/thumb/723/722531-0006.gif)
![[분자생물학] G-CSF-7](http://images.happyhaksul.com/thumb/723/722531-0007.gif)
![[분자생물학] G-CSF-8](http://images.happyhaksul.com/thumb/723/722531-0008.gif)
![[분자생물학] G-CSF-9](http://images.happyhaksul.com/thumb/723/722531-0009.gif)
![[분자생물학] G-CSF-10](http://images.happyhaksul.com/thumb/723/722531-0010.gif)
![[분자생물학] G-CSF-11](http://images.happyhaksul.com/thumb/723/722531-0011.gif)
![[분자생물학] G-CSF-12](http://images.happyhaksul.com/thumb/723/722531-0012.gif)
![[분자생물학] G-CSF-13](http://images.happyhaksul.com/thumb/723/722531-0013.gif)
![[분자생물학] G-CSF-14](http://images.happyhaksul.com/thumb/723/722531-0014.gif)
![[분자생물학] G-CSF-15](http://images.happyhaksul.com/thumb/723/722531-0015.gif)
![[분자생물학] G-CSF-16](http://images.happyhaksul.com/thumb/723/722531-0016.gif)
![[분자생물학] G-CSF-17](http://images.happyhaksul.com/thumb/723/722531-0017.gif)
![[분자생물학] G-CSF-18](http://images.happyhaksul.com/thumb/723/722531-0018.gif)
![[분자생물학] G-CSF-19](http://images.happyhaksul.com/thumb/723/722531-0019.gif)
![[분자생물학] G-CSF-20](http://images.happyhaksul.com/thumb/723/722531-0020.gif)
분야
pptx02 Indication
03 Mechanism of drug action
04 Recombinant technology
05 Dosage form & Medication method
06 Product Type & Adverse reation
07 Reference
2. History of development
1960s
Discovery of colony-stimulating factors (CSF)
1980s
GM-CSF, M-CSF, G-CSF and multi-CSF
The human G-CSF was cloned
Usage for the treatment at first
1990s
first approval of Filgrastim by the US Food and Drug Administration
Launched Lenograstim
2000s
Launched PEG-filgrastim
Karl Welte G. Molineux et al. (eds.), Twenty Years of G-CSF, Milestones in Drug Therapy,
2) Mobilization of plasma cells in healthy individuals treated with granulocyte colony-stimulating factor for haematopoietic stem cell collection
3) Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells
Masayuki Tsuchiya, Hitoshi Nomura, Shinetaka Asano, Yoshio Kaziro and Shigekazu Nagata
4) High level expression of a cDNA for human granulocyte colony stimulating factor in Chinese hamster ovary cells.
5) Characteristics of Hematopoitic Growth Factor, G-CSF and Its Clinical Vision
Jeonghae Park1, Jung-Ae Park1, Seok-Woo Kang2, Tae-Won Goo2 and Kyung Tae Chung1*
Homodimeric Crossover Structure of the Human GCSF-Receptor Signaling Complex, Proceeding of the National Academy of Sciences of the United States of America, 103, 2006, p.3135-3140
Granulocte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders
Ivo P. Touw and Gert-Jan M. van de Geijn, Department of Hematology, Erasmus University Medical Center
