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Obesity as an independent predictive factor for pathologic complete response after neoadjuvant chemoradiation in rectal cancer -
분야 의약학 > 호르몬
저자 Soo Young Lee Chang Hyun Kim Young Jin Kim Han Deok Kwak Jae Kyun Ju Hyeong Rok Kim
발행기관 대한외과학회
간행물정보 Annals of Surgical Treatment and Research 2019년, Annals of Surgical Treatment and Research Vol.96 No.3, 116page~122page(총7page)
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목차
부제 :
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
 
 
영문초록
Purpose: The predictive role of obesity on pathologic complete response (pCR) after neoadjuvant chemoradiation (nCRT) in rectal cancer remains controversial. This study aimed to evaluate the association between obesity and pathologic response in patients with rectal cancer following nCRT.
Methods: A total of 320 patients with primary rectal cancer who underwent curative resection after nCRT between January 2010 and September 2014 were enrolled in this study. Obesity was defined as body mass index of ≥25 kg/m². Clinicopathologic characteristics were analyzed to identify independent predictive factors for pCR.
Results: Among the included patients, 23.4% (n = 75) were obese, and 14.7% (n = 47) showed pCR. Baseline characteristics were generally similar between obese and nonobese patients, except that women (P = 0.001) and cT2 tumors (P = 0.001) were more common in the obese group. Multivariate logistic regression analysis revealed that obesity (odds ratio [OR] = 2.051; 95% confidence interval [CI], 1.009-4.168), cT2 (OR, 3.614; 95% CI, 1.166-11.202), and pretreatment carcinoembryonic antigen <5 ng/mL (OR, 2.921; 95% CI, 1.365-6.253) were independent predictors for pCR. Obesity was not associated with disease-free survival or local recurrence-free survival.
Conclusion: Obesity was an independent predictive factor for pCR following nCRT in rectal cancer, but was not associated with recurrence. Further studies are needed to clarify the association between obesity and prognosis of rectal cancer after nCRT.
 
 
Neoadjuvant chemoradiation, Rectal cancer, Obesity
 
 
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