Purpose The purpose of this study was to evaluate the effects of cold therapy and thermal therapy, and immunoreactivity of vascular endothelial growth factor (VEGF), Interleukin-1(IL-1) and Interleukin-6(IL-6) on angiogenesis after muscle contusion injury. Methods Muscle contusion injury was induced in the gastronemius muscle by dropping a metal bead (22.8g). Cold and thermal theraphy was applied immediately and directly to the skin of injured muscle daily for three days. (experimental group-1 5 cold pack, experimental group-2 50℃ hot pack, control group non applied, treatment time 10minutes) Results The experimental group-1 and 2 showed higher immunoreactivity of VEGF, IL-1, IL-6 than control group during 3 days(P<0.05). And the experimental group-2 showed higher than the experimental group-1 especially VEGF(P<0.05). Conclusion There data thermal therapy was more effective than cold therapy in the acute muscle contusion injury.