Sjogren`s syndrome is a chronic autoimmune disease characterized by decreased function of the lacrimal and salivary glands. In addition, many other organs can be involved in patients with Sjogren`s syndrome. Overt or latent renal tubular acidosis is an uncommon extraglandular manifestation in Sjogren`s syndrome, and osteomalacia is a rare complication of renal tubular acidosis. It has been rarely reported that osteomalacia is associated with distal renal tubular acidosis in patients with Sjogren`s syndrome. We report a case of a 34-year-old female patient who was initially presented with muscle weakness in both lower extremities. The patient was then diagnosed with Sjogren`s syndrome complicated by osteomalacia and renal tubular acidosis.