We consider a problem of patient flow in emergency department. This paper provides the appropriate model that would facilitate the quality and safety to redesign the partnership between engineering and healthcare to meet the real needs of patients in hospital. The focus is on the modeling and computer simulation of the general inpatient flow in the emergency department at a clinic, for the patients of sepsis resuscitation before moving the patient to the intensive care unit. Discrete event simulation is done to identify and improve patient flow, primarily reducing the total waiting time. Our study greatly enhanced managers` understanding of the potential maximum capacity of the department and how patient flow is influenced by process changes and resource availability while a patient is still in emergency department and not yet admitted to an intensive care unit.