Articles : Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
분야
의약학 > 약화학
저자
( Sung Jin Lee ) , ( Hyun Jin Ahn ) , ( Kung Woo Nam ) , ( Kyeong Ho Kim ) , ( Woong Chon Mar )
발행기관
한국응용약물학회
간행물정보
Biomolecules & Therapeutics(구 응용약물학회지) 2012년, 제20권 제5호, 487~491쪽(총5쪽)
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53902304.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mM H2O2, as assessed by 4`,6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.
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