Association between single nucleotide polymorphisms of TRPV-1 gene and patients with irritable bowel syndrome in Korean populations
의약학 > 내과학
( Dae Ho Cho ) , ( Gi Hoon Lee ) , ( Dong Keun Cho ) , ( Kang Jin Park ) , ( Young A Song ) , ( Sung Bum Cho ) , ( Wan Sik Lee ) , ( Chang Hwan Park ) , ( Hyun Soo Kim ) , ( Sung Kyu Choi ) , ( Jong Sun Rew ) , ( Young Eun Joo )
대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 65(총1쪽)
42846281.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    30원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    Transient receptor potential vanilloid type 1 (TRPV-1) plays a crucial role in pain perception and development of hyperalgesia, and its expression is up-regulated in patients with irritable bowel syndrome (IBS). Although several non-synonymous single nucleotide polymorphisms (SNPs) in human TRPV-1 gene have been identified, there is no information about their pathobiological significance in IBS. The aim of this study was to investigate potential association between SPNs of the TRPV-1 gene and patients with IBS. Methods: We chose to focus on three SNPs in human TRPV-1 coding region (rs222749, rs9894618 and rs222747) in 80 healthy control and 104 IBS patients. We developed the high resolutional melting (HRM) method to determine the genotyping of the rs222747 and rs9894618 and the genotyping of the rs222749 was also determined by direct sequencing method. Results: The CG genotype of the rs222747 was 58.8% (47/80) in controls and 46.2% (48/104) in IBS patients (OR 0.581, 95% CI 0.277-1.217, p=0.150). The GG genotype of the rs222747was 15.0% (12/80) in controls and 20.2% (21/104) in IBS patients (OR 1.135, 95% CI 0.428-3.009, p=0.798).The CT genotype of the rs222749 was 31.3% (25/80) in control group and 31.7% (33/104) in IBS patients (OR 1.145, 95% CI 0.568-2.308, p=0.705). There was no significant difference in allele frequency of the SNPs of TRPV-1 gene between healthy control and IBS patients. Conclusion: These results suggest that the SNPs of TRPV-1 gene may not be associated with IBS in Korean populations. Further studies with large cases are needed to validate the results of the present study.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일
    copyright (c) 2009 happynlife. steel All reserved.