A case of autoimmune hepatitis associated with Sjogren`s syndrome
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Autoimmune hepatitis is a chronic unresolving inflammation of the liver characterized by hypergammaglobulinemia, circulating auto-antibodies, and the presence of interface hepatitis and portal plasma cell infiltration on histological examination. It can be associated with numbers of other autoimmune diseases. Overlap syndromes of AIH with primary biliary cirrhosis or primary sclerosing cholangitis are frequent, however, Sjogren`s syndrome is rarely associated with autoimmune hepatitis. We report an unusual case of autoimmune hepatitis associated with Sjogren`s syndrome. A 56-year-old woman was admitted because of abnormal liver enzymes. She was not taking medications and not a drinker. Her laboratory tests showed negative viral hepatitis markers, increased serum IgG level, and positive anti-nuclear antibody. Based on characteristic clinical features, live histologic features, serology, positive Schirmer`s test, and salivary scintigraph, the diagnosis of auto-immune hepatitis and Sjogren`s syndrome were made. Her clinical symptoms and abnormality of liver test improved with prednisolone and azathioprine and she achieved complete remission.
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