Usefulness of ECG for The Prediction of Right Ventricular Dysfunction and Treatment Strategy In Patients with Acute Pulmonary Thromboembolism
의약학 > 내과학
( Ki Hong Lee ) , ( Jeong Gwan Cho ) , ( Donghan Kim ) , ( Min Goo Lee ) , ( Keun Ho Park ) , ( Doo Sun Sim ) , ( Nam Sik Yoon ) , ( Hyun Ju Yoon ) , ( Kye Hun Kim ) , ( Young Joon Hong ) , ( Ju Han Kim ) , ( Youngkeun Ahn ) , ( Myung Ho Jeong ) , ( Jong
대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 132(총1쪽)
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    Background and study objective: Electrocardiographic (ECG) findings for the diagnosis of acute pulmonary thromboembolism (PTE) are well known. However, those for the prediction of right ventricular dysfunction (RVD) and for the utilization in treatment strategy in patients with PTE are not fully understood. Subject and methods: We analyzed 12-lead ECG, echocardiography and laboratory finding of 71 patients (27 males, 67.7±13.3 years old) with the diagnosis of acute PTE at Chonnam National University Hospital, between July 2008 and July 2011. The diagnosis of PTE was confirmed by computer tomography. The ECG analysis included 21-point ECG score, S1Q3T3 complex, S1Q3T3T4 complex, Q3T3V3 complex and Q3T3T4 complex. Patients with one of the following were considered to have RVD in echocardiogram: RV dilatation, RV free wall hypokinesia, or D-shape LV. Complicated in-hospital events (CIHE) was defined as need for vasopressor, thrombolysis, Inferior vena cava (IVC) filter, resuscitation, the presence of shock index >1(heart rate/systolic blood pressure) or death. Results: A value >3 in the 21 ECG score was the most frequent ECG finding in patients with PTE. The area under the ROC curve to assess 21-point ECG score to predict thrombolysis and CIHE were 0.62 (95% CI 0.59-0.85), 0.61 (95% CI 0.56-0.75). The sensitivity and specificity for the value >3 points in the prediction of CIHE were 93% and 83%. In the ECG and laboratory findings, A value >3 in the 21 ECG score (42.9% vs. 88.9%, p=0.01), S1Q3T3 complex (27.3% vs. 45.8%, p=0.037) were only statistically significant predictors in RVD. However, S1Q3T3T4 complex and Q3T3V3 complex were only statistically significant predictors for the utilization of thrombolysis (8.8% vs. 27.0%, p=0.048; 14.7% vs. 37.8%, p=0.028, respectively) and CIHE (12.0% vs. 24.5%, p=0.02; 5.6% vs. 34.0%, p=0.019). Conclusion: Standard ECG might be useful in the prediction of RVD, prognosis, and treatment strategy as well as the diagnosis in patients with PTE.
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