Associations between high-sensitivity C-reactive protein and ankle brachial index in asymptomatic older adults
분야
의약학 > 내과학
저자
( Jae Yong Yoon ) , ( Hyun Jun Cho ) , ( Kyun Hee Kim ) , ( Won Suk Choi ) , ( Sun Hee Park ) , ( Myung Hwan Bae ) , ( Jang Hoon Lee ) , ( Dong Heon Yang ) , ( Hun Sik Park ) , ( Yongkeun Cho ) , ( Shung Chull Chae ) , ( Jae Eun Jun ) , ( In Kyu Lee ) , (
발행기관
대한내과학회
간행물정보
대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 133(총1쪽)
파일형식
42846416.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    1,000원
    적립금
    30원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Background: The aims of this study were to determine (1) the prevalence of an abnormal ankle brachial index (ABI; <0.90) and (2) the association of serum high sensitive C-reactive protein (hs-CRP), a marker of systemic inflammation, with the abnormal ABI in asymptomatic older adults (>50 years old). Methods: Study subjects were 1,271 Koreans (263 males; mean age=65.8±8.5 year-old) in a rural area in Daegu city, Korea. They were enrolled from August to November 2008 for a cohort study. The ABI was performed after subjects rested for at least 10 minutes in a supine position. Study subjects were classified into a low (ABI <0.9) and normal ABI group. Baseline levels of serum hs-CRP were measured by immunoturbidimetric assay. Results: Of 1,271 asymptomatic older adults, 42 (3.3%) had a lower ABI. Based on univariate analysis for low ABI, age, gender, body mass index, systolic blood pressure, status of smoking, diabetes mellitus, and serum level of uric acid were significantly related to a lower ABI. Baseline hs-CRP levels were significantly higher in low ABI group compared to normal ABI group (2.34±2.41 mg/L versus 1.46±1.38 mg/L, p=0.023). Baseline hs-CRP levels were significantly negatively correlated with ABI (r=-0.142, p<0.001). In multivariate analysis log transformed hs-CRP (odds ratio [OR] 2.639, 95% confidence interval [CI] 1.026-6.787; p=0.044) in addition to age(OR 1.082, 95% CI 1.035-1.131; p=0.001) were independent predictors of low ABI after adjusting for gender, body mass index, systolic blood pressure, status of smoking, diabetes mellitus, and serum level of uric acid. The likelihood ratio test showed that hs-CRP added incremental value to the combination of serum uric acid concentrations and conventional risk factors in predicting low ABI. Conclusions: This study provides evidence that baseline levels of hs-CRP are modestly associated with low ABI. These data suggest that inflammation may have a potentially important role in part in the development of peripheral vascular disease in asymptomatic older adults.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.