Iatrogenic femoral pseudoaneurysm(IPA) is a troublesome complication related to the femoral arterial access site used for invasive cardiovascular procedures. Several therapeutic strategies have been developed to treat these complications. They include ultrasound-guided compression repair(UGCR), surgical repair, and minimally invasive percutaneous treatments(thrombin injection, coil embolization and insertion of covered stents). Traditionally, surgical repair has been the main treatment for FAP, especially when pseudoaneurysm larger than 4 cm is indicated or when anticoagulation or GP-IIb/IIIa inhibitors are extensively used during the procedure. Recently, UGCR has become the first-line treatment of pseudoaneursms at many institutions. However, the procedure may be very painful, and has a relatively high recurrence rate in patients receiving anticoagulant therapy. Ultrasound-guided thrombin injection has gained populality because of high success rate and minimal complication. Here, We report a case of a giant pseudoaneurysm in a deep femoral artery, which had developed as a complication of endovascular intervention for peripheral arterial occlusive disease via deep femoral artery, was successfully obliterated using ultrasound-guided thrombin injection.