Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer
의약학 > 내과학
( Yu Mi Lee ) , ( Soo Young Lee ) , ( Sun Jung Kwon ) , ( Eugene Choi ) , ( Moon Jun Na ) , ( Young Jin Kim ) , ( Hyun Min Cho ) , ( Jae Ku Kang ) , ( Ji Woong Son )
대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 177(총1페이지)
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    Histone deacetylases (HDACs) play a crucial role in tumorigenesis. Over-expression of HDACs has been reported in lung cancer. The mechanism of highly expressed HDAC1 in lung cancer has yet not been determined. In the present study, we showed that miR-449a/b regulates HDAC1 by directly binding with the 3`untranslated region of the HDAC1. The expression of miR-449a/b was down-regulated and the expression of HDAC1 was up-regulated in primary lung cancer. The down expression of miR-449a/b might be one mechanism for over-expression of HDAC1 in lung cancer. miR-449a/b inhibited cell growth and anchorage-independent growth. Furthermore, co-treatment with miR-449a and HDAC inhibitors had a significant growth reduction compared with HDAC inhibitors mono-treatment. These results suggest that miR-449a/b may has a tumor suppressor function and might be a potential therapeutic candidate in patients with primary lung cancer.
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