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Influence of stem cell mobilization after cyclophosphamide, thalidomide and dexamethasone regimen in patients with newly diagnosed multiple myeloma
분야 의약학 > 내과학
저자 ( Sung Hoon Jung ) , ( Deok Hwan Yang ) , ( Jae Sook Ahn ) , ( Soo Young Bae ) , ( Yeo Kyeoung Kim ) , ( Hyeoung Joon Kim ) , ( Je Jung Lee )
발행기관 대한내과학회
간행물정보 대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 262(총1쪽)
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연관 논문
The effect of the dexamethasone, cytarabine, and cisplatin (DHAP) regimen on stem cell mobile-zation and transplant outcomes of patients with non-Hodgkin’s lymphoma who are candidates for up-front autologous stem cell transplantation
Cyclophosphamide-containing regimen (TCD) is superior to melphalan-containing regimen (MPT) in elderly MM patients with renal impairment
Original Articles : Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study
Poster Session : PS 1410 ; Hemato-Oncology(Hematology) : Cytomegalovirus Reactivation Following Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma with Extramedullary Plasmacytoma
A Combination of Melphalan, Prednisone, and 50 mg Thalidomide Treatment in Non-Transplant-Candidate Patients with Newly Diagnosed Multiple Myeloma
 
 
영문초록
Backgrounds: CTD regimen has been known as an effective induction therapy in patients with newly diagnosed MM. But, there were inconsistent results for the autologous stem cell yield for transplantation. The aim of present study was to identify the influence of CTD therapy on outcome of peripheral blood stem cell (PBSC) collection. Methods: Forty-eight patients received 4 cycles of CTD therapy. Stem cells were mobilized with cyclophosphamide (3.0 g/m2) and G-CSF (10 g/kg, daily) or G-CSF alone. Patients failing to collect ≤ 4.0×106 CD34+ cells/kg received a second mobilization courses. Results: The median age at diagnosis was 56 years (range, 39-69). Median duration from start of CTD therapy to first collection was 4.6 months (range, 3.3-8.7). Forty-four patients were mobilized with cyclophosphamide following with G-CSF and 4 patients with G-CSF alone. The median day of apheresis was 3 days (range, 2-7). The response rate for CTD regimen at mobilization was 10% (5/48) of CR, 25% (12/48) of VGPR and 63% (30/48) of PR. A median number of harvested CD34+ cells was 8.6×106 cells/kg. At the first mobilization, 83% (40/48) of patients had been reached the minimal PBSC collection target of ≥ 2.0×106 CD34+ cells/kg and 71% (34/48) of patients achieved the collection ≥ 4.0 x 10^6 CD34+ cells/kg. At the end of second mobilization, 90%(43/48) of patients had yields of at least ≥ 2.0×106 CD34+ cells/kg and 77% (37/48) of patients had yields of ≥ 4.0×106 CD34+ cells/kg. During mobilization period, three patients were developed grade 3/4 non-hematologic adverse events. Conclusion: CTD regimen is an effective induction therapy in patients with newly diagnosed MM showing high response rate and acceptable rate of autologuos stem cell yield without any detrimental effect for the following stem cell collection.
 
 
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