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The impact of vascular micro-calcification of radial artery on cardiovascular mortality in hemodialysis patients
분야 의약학 > 내과학
저자 ( Min Young Lee ) , ( Yu Seon Yun ) , ( Young Ok Kim ) , ( Sun Ae Yoon ) , ( Keun Suk Yang )
발행기관 대한내과학회
간행물정보 대한내과학회 추계학술발표논문집 2011년, 제2011권 제1호, 237(총1쪽)
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연관 논문
Pathologic change accompanied by vascular micro-calcification of radial artery in hemodialysis patients
Pre-existing arterial pathologic changes affecting arteriovenous fistula patency and cardiovascular mortality in hemodialysis patients
The Korean Association of lnternal Medicine : Poster Session ; PS 1338 : Nephrology ; Arterial Micro-Calcifi cation is Associated with Coronary Artery Calcium Score in Hemodialysis Patients
The Korean Association of lnternal Medicine : Poster Session ; PS 1337 : Nephrology ; The Impact of Pre-Existing Arterial Micro-Calcifi cation of the Vascular Access on Early AVF Failure in Incident Hemodialysis Patients
Original Article : Association of Arterial Stiffness with the Decrease of Post- Dialysis Blood Pressure in Maintained Hemodialysis Patients
 
 
영문초록
Background: Vascular gross calcification by imaging study is common in hemodialysis (HD) patients, and it is a significant predictor for cardiovascular mortality in HD patients. But vascular micro-calcification (VMC) by pathologic study has been rarely reported. Recently, we have reported that VMC is associated with vascular access failure as well as aortic stiffness (2010 ASN). The aim of this study was to determine the impact of VMC of radial artery on cardiovascular mortality in uremic patients receiving vascular access operation. Methods: One-hundred forty nine HD patients (Mean age; 59.0±13.9 years, Male/Female; 86/63, Percent of diabetes mellitus; 65.8%) receiving vascular access operation were included in this study. During the operation, we obtained partial arterial specimen and performed pathologic examination by von Kossa stain to identify VMC. We investigated cardiovascular mortality for at least 1 year after the operation. Finally we compared clinical and laboratory findings, and cardiovascular mortality between the patients with VMC and those without VCM. Results: Mean duration of follow-up was 37.8±34.5 months and the incidence of VCM was 38.8% (n=57). Diabetes (OR 4.138, 95% CI 1.631-11.830, p=0.002) and peripheral artery disease (OR 9.958, 95% CI 1.021-1339.97, p=0.048) were independent predictors for VCM. Serum parameters were not significantly related to VMC. During the period of flow up, there were 27 cardiovascular deaths. Kaplan-Meier analysis showed an increased cardiovascular mortality risk (HR 2.613, 95% CI 1.196-5.711, p-value=0.016) in VMC group, and Cox regression analysis confirmed that VMC was an independent predictor for cardiovascular mortality (HR 2.352, 95% CI 1.087-5.088, p-value=0.030). Conclusion: This study demonstrates that VMC is a strong risk factor of cardiovascular mortality in HD patients.
 
 
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