The goals of palliative chemotherapy are to improve overall survival and the quality of life through relief of symptoms.The other hand, chemotherapy has many side effects such as myelosupression, neuropathy, gastro-intestinal symptom and infertility. In many known side effects of chemotherapy, bleeding occurs in approximately 6-10% of patients with advanced cancer. Most of bleeding is local vessel damage and systemic process such as disseminatated intravascular coagulopathy, abnormalities in platelet function or number after chemotherapy. There is no article about chemotherapy response related bleeding. However, bleeding may occur in chemo-sensitive tumor like lymphoma and in pre radiotherapy patient such as head and neck cancer, rectal cancer after chemotherapy. There are three cases of pure chemotherapy response related bleeding without other bleeding condition. One is pre-radiotherapy given maxillary sinus cancer, another is chemo sensitive gastric cancer and the last case is pre-radiotherapy given rectal cancer. These all cases had a massive bleeding after chemotherapy without other bleeding condition and successful management variable method such as embolization, endoscopy, and thrombotic agent.