The purpose of this study was to compare with uveitis accompanied rheumatic disease and uveitis unaccompanied rheumatic disease in immunosuppressive therapy response. An observational study was conducted of 432 patients diagnosed with uveitis who visited the rheumatologic department to evaluate with rheumatic disease between 2000 and 2009. We divided patients into two groups: uveitis related to rheumatic disease and unrelated to rheumatic disease. All patients were treated and a response to treatment was measured at the end of the observation period. The 432 patients were diagnosed to uveitis, 33 (7.6%) patients had rheumatic diseases related uveitis and 399 (92.4%) patients had uveitis unrelated rheumatic disease. the each group were similar to gender and body mass index. but the mean age at onset of uveitis was younger uveitis with rheumatic disease than uveitis without rheumatic disease(44.06 vs 48.23 years). The rheumatic disease accompanied uveitis was consisted of spondyloarhtropathy (31%), bechet`s disease (27%), rheumatoid arthritis (18%), systemic lupus erythematosus (15%), sjogren`s syndrome (6%) and mixed connective tissue disease (3%). The state of inflammation, ESR and CRP levels in patients with uveitis associated with rheumatic diseases were increased but the ocular complications did not increase in uveitis associated with rheumatic disease. The response of immunosuppressive therapy in patients with uveitis associated with rheumatic diseases was good and was statistically significant (p<0.05). The uveitis accompanied rheumatic disease was better response to immunosuppressive therapy and less frequent complications than uveitisu naccompanied rheumatic disease in early treatment.