In the Donguebogam it is written that nephrite well waters, which are derived from the mountain where nephrite is produced, has wide medical effects to let man keep healthy body, black hair and long live. However, nephrite itself has limited medical effects to cure stomach fever, tightness in the chest, asthma and thirstiness. This investigate is to study mineralogically, geochemically and oriental medically how it is possible that the nephrite well waters have wider medical effects in comparison to nephrite with limited medical effects. Nephrite consists of tremolite Ca2Mg5Si8O22(OH)2, which is called actinolite Ca2(Mg,Fe)5Si8O22(OH)2 when its Mg is partly replaced by Fe (<10%). The tremolite is generally associated with talc, calcite and chlorite in the ore deposit formed by the hydrothermal solutions from granitic intrusives in the dolomite and dolomitic limestone areas in Korea. These five minerals of nephrite, actinolite, talc, calcite and chlorite are all recorded in the Donguebogam (Heo Jun, 1613) and Bonchogangmog (Lee Si Jin, 1578) as medical minerals to cure various diseases. Therefore, waters derived from nephrite deposits may contain chemical compositions related to not only nephrite but also the other medical minerals and have wider medical effects than nephrite itself.