Antibacterial Activity of Triterpenoids from Clerodendron trichotomum
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The aim of this research was to investigate theantibacterial activity of Clerodendron trichotomum. Antibacterialactivities of the n-hexane, methylene chloride (MC), ethyl acetate,and n-butanol fractions from C. trichotomum were tested againstStaphylococcus aureus, Escherichia coli, and Helicobacter pylori.The n-hexane and MC fractions showed antibacterial activityagainst H. pylori at a concentration of 1.7mg/mL and showedinhibition zones of 10 and 11mm in disc assay, respectively.Further testing of 22-dehydroclerosterol and B-amyrin (each 3.4mg/mL) from the MC fraction of C. trichotomum revealedmoderate antibacterial effects against E. coli, S. aureus, and H.pylori. In particular, B-amyrin showed clear zones of 12 and 13mm against E. coli and H. pylori, respectively, suggesting itspotential as an antibacterial agent. The active compounds from C.trichotomum might provide a promising therapeutic agent againstinfections by E. coli, S. aureus, and H. pylori.
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