Invited Mini Review : AMP-activated protein kinase: implications on ischemic diseases
자연과학 > 화학
( Yong Joo Ahn ) , ( Hwe Won Kim ) , ( Hee Jin Lim ) , ( Max Lee ) , ( Yu Hyun Kang ) , ( Sang Jun Moon ) , ( Hyeon Soo Kim ) , ( Hyung Hwan Kim )
생화학분자생물학회(구 한국생화학분자생물학회)
BMB Reports 2012년, 제45권 제9호, 489~495페이지(총7페이지)
02618093.pdf [무료 PDF 뷰어 다운로드]
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    Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel. When an organ cannot receive oxygenated blood and can therefore no longer replenish its blood supply due to ischemia, stresses, such as the disruption of blood glucose homeostasis, hypoglycemia and hypoxia, activate the AMPK complex. LKB1 and CaMKKβ are essential activators of the AMPK signaling pathway. AMPK triggers proangiogenic effects through the eNOS protein in tissues with ischemic conditions, where cells are vulnerable to apoptosis, autophagy and necrosis. The AMPK complex acts to restore blood glucose levels and ATP levels back to homeostasis. This review will discuss AMPK, as well as its key activators (LKB1 and CaMKKβ), as a central energy regulator and evaluate the upstream and downstream regulating pathways of AMPK. We will also discuss how we can control this important enzyme in ischemic conditions to prevent harmful effects in patients with vascular damage. [BMB Reports 2012; 45(9): 489-495]
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