Invited Mini Review : The roles of FADD in extrinsic apoptosis and necroptosis
분야
자연과학 > 화학
저자
( Eun Woo Lee ) , ( Jin Ho Seo ) , ( Man Hyung Jeong ) , ( Sang Sik Lee ) , ( Jae Whan Song )
발행기관
생화학분자생물학회(구 한국생화학분자생물학회)
간행물정보
BMB Reports 2012년, 제45권 제9호, 496~508페이지(총13페이지)
파일형식
02618094.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negative FADD transgenic mice result in embryonic lethality and an immune defect without showing apoptotic features. Numerous studies have suggested that FADD regulates cell cycle progression, proliferation, and autophagy, affecting these phenomena. Recently, programmed necrosis, also called necroptosis, was shown to be a key mechanism that induces embryonic lethality and an immune defect. Supporting these findings, FADD was shown to be involved in various necroptosis models. In this review, we summarize the mechanism of extrinsic apoptosis and necroptosis, and discuss the in vivo and in vitro roles of FADD in necroptosis induced by various stimuli. [BMB Reports 2012; 45(9): 496-508]
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