Purpose: The purpose of this study was to investigate agitation in home-dwelling persons with dementia and coping behaviors of primary family care-givers to agitation. Methods: The research was designed as a descriptive study. A total of two hundred and five subjects had participated in this study. To measure agitation in persons with dementia, Cohen-Mansfield Agitation Inventory was used. To measure coping behaviors of primary family care-givers to the agitation, a questionnaire was used. Descriptive statistics, t-test, ANOVA, Scheffe` test were used to answer the research objectives. Results: ``Repetitive mannerisms`` and ``repeating sentences`` were the most commonly occurred agitation in home-dwelling persons with dementia. ``Leaving the situation``, ``allowing certain time``, and ``soothing by talking`` were the most common coping behaviors occurred in primary care-givers. Conclusion: The findings of the current study would provide meaningful data to develop nursing programs to control agitation for home-dwelling persons with dementia and education programs for primary care-givers to cope with persons` agitation.