대장암에 대한 장내 미생물 무리의 영향과 프로바이오틱스
분야
의약학 > 내과학
저자
명대성 ( Dae Seong Myung ) , 주영은 ( Young Eun Joo )
발행기관
대한소화기학회
간행물정보
대한소화기학회지 2012년, 제60권 제5호, 275~284페이지(총10페이지)
파일형식
07811282.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The human intestinal microbiota is a community of 1013-1014 microorganisms that harbor in the intestine and normally participate in a symbiotic relationship with human. Technical and conceptual advances have enabled rapid progress in characterizing the taxonomic composition, metabolic capacity and immunomodulatory activity of the human intestinal microbiota. Their collective genome, defined as microbiome, is estimated to contain ≥150 times as many genes as 2.85 billion base pair human genome. The intestinal microbiota and its microbiome form a diverse and complex ecological community that profoundly impact intestinal homeostasis and disease states. It is becoming increasingly evident that the large and complex bacterial population of the large intestine plays an important role in colorectal carcinogenesis. Numerous studies show that gut immunity and inflammation have impact on the development of colorectal cancer. Additionally, bacteria have been linked to colorectal cancer by the production of toxic and genotoxic bacterial metabolite. In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer and role for probiotics in the prevention of colorectal cancer. (Korean J Gastroenterol 2012;60:275-284)
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