원저 : Lipopolysaccharide에 의한 심장조직의 염증 반응과 심근 기능 이상에 대한 Fenofibrate의 조절 효과
분야
의약학 > 일반외과학
저자
송동훈 ( Dong Hoon Song ) , 황용 ( Yong Hwang ) , 유수진 ( Su Jin Yoo )
발행기관
대한응급의학회
간행물정보
대한응급의학회지 2012년, 제23권 제5호, 721~729쪽(총9쪽)
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18402517.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Purpose: This study was intended to establish experimental conditions for monitoring the cardioprotective effects of fenofibrate on cardiac function in lipopolysaccharide (LPS)- stimulated BalB/c mice. Methods: To investigate the effects of fenofibrate on cardiac function, expression of Peroxisome proliferator-activated receptors (PPARs) and Peroxisome proliferator-activated receptor Gamma coactivator 1(PGC-1) and its target gene in the heart tissues of mice was compared after controls and LPS injection with pretreated fenofibrate or alone using reverse transcriptase-polymerase chain reaction (RTPCR), Western blot analysis, and immunohistochemistry. In addition, Enzyme-linked-immunosorbent-assays (ELISA) were performed for assessment of pro-inflammatory cytokines of blood serum. Results: Pretreated with fenofibrate had protective effects of diminishing the levels of LPS-induced pro-inflammatory cytokines, including interleukin-1β(IL-1β), interleukin-6 (IL- 6), and tumor necrosis factor-α(TNF-α) and recovery from reduction of messenger Ribo-nucleic acid, protein level of PPARs and PGC-1 in LPS-administered heart tissue. In addition, increasing expression of PPARs and PGC-1 ameameliorated the expression and activity of catalase blocked production of lipid peroxidation. Conclusion: Treatment with fenofibrate resulted in augmented expression of transcription factors and reduced production of pro-inflammatory cytokines and lipid peroxidation after LPS administration. Therefore, results of this study suggested that fenofibrate should not only have a protective effect but should also restore cardiac function in several cardiac dysfunctional situations.
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