The effect of Saururus chinensis Baill against oxidative damage and inflammation
분야
의약학 > 기초한의학
저자
( Dong Ryeol Hwang ) , ( Jin Boo Jeong ) , ( Hyun Ji Eo ) , ( Se Chul Hong ) , ( Ji Hyun Yoo ) , ( Kun Hee Lee ) , ( Bo Ram Kim ) , ( Jin Suk Koo )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2012년, 제27권 제6호, 1~6쪽(총6쪽)
파일형식
35301196.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,000원
    적립금
    120원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Objectives: ROS are involved in a wide spectrum of diseases including chronic inflammation and cancer. S.chinensis Baill, a perennial herb commonly called Chinese lizard`s tail or Sam-baek-cho in Korea, is used for the treatment of edema and inflammatory diseases in the Oriental folk medicine. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the two extracts, water (WE) and ethyl acetate (EAE) from S.chinensis Baill. Methods: Anti-oxidant activity was evaluated using Fe2+ chelating and hydroxyl radical scavenging assay. DNA cleavage assay, and western blot and immunostaining for phospho-p65 were performed to evaluate anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell. Results: In Fe2+ chelating activity and hydroxyl radical scavenging activity, WE showed more strong scavenging activity for hydroxyl radical than EAE. WE scavenged hydroxyl radical by 12% at 3.2 ㎍/ml, 21% at 16 ㎍/ml, 32% at 80 ㎍/ml, 66% at 400 ㎍/ml and 82% at 2000 ㎍/ml, respectively. In addition, WE showed more strong chelating activity than EAE. WE chelated Fe2+ ion by 1.1% at 3.2 ㎍/ml, 8.2% at 16 ㎍/ml, 26.3% at 80 ㎍/ml, 72% at 400 ㎍/ml and 89% at 2000 ㎍/ml, respectively. Also, WE inhibited oxidative damage via its anti-oxidant activity. In anti-inflammatory effect, EAE inhibited NO production and iNOS expression. In addition EAE suppressed the NF-κB and MAPK signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions: Together, these data indicate that S. chinensis Baill, shows anti-oxidant activity and anti-inflammatory effect.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.