가감산조인탕(加減酸棗仁湯)이 만성 스트레스 모델 쥐에 대한 항스트레스 효과
분야
의약학 > 기초한의학
저자
권혁진 ( Hyuk Jin Kwon ) , 김경섭 ( Kyeng Sub Kim ) , 강수경 ( Su Kueng Kang ) , 박필상 ( Pil Sang Park ) , 유지연 ( Ji Min Lim ) , 임지민 ( Ji Min Lim ) , 조용식 ( Yong Sik Cho ) , 최윤희 ( Yoon Hee Choi ) , 박신영 ( Shin Young Park )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2012년, 제27권 제6호, 29~35쪽(총7쪽)
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35301200.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: To observe the effect of 4 kinds of Korean medicine and complex extracts on the anti-stress of chronic mild stress Rat model, so as to find out the machanism of its pharmacological effects. Methods: 64 healthy SD Rats were randomly divided into 8 groups. Model Design by chronic stress (CSM), and carried out the forced swimming test, We investigated the body weight, feed and water intake, feed conversion ratio and measured parameters to changes in swimming time, immobility time, 2 and 24 hours of feces, corticosterone hormone and blood glucose level, Results: In this experiments, body weight gain and feed intake were higher in all korean medicinal herb group, Swimming time were increased by Zizyphus jujuba and Gagamsanzointang (SZT) groups and immobility time was significantly lower by Zizyphus jujuba and Fluoxetine (FLX) groups. The result of corticosterone hormone level were significantly lower in Fluoxetine(FLX) and Gagamsanzointang (SZT) but blood glucose was not significantly difference, In 2 hours after fecal frequency result were significantly lower in Zizyphus jujuba group, but SZT group were increased, This result caused by acute stress but 24 hours of feces were restored to normal. Conclusions: 5 kind of Korean Medicinal Herbs extracts has good anti-stress effects, and also to clear the circulatory system and regulate blood glucose and improve bowel function. We suggest that use a single Korean medicine rather than the combination to relieve stress.
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