갈근 에탄올추출물의 국소뇌허혈 모델에 대한 뇌신경보호 효과
분야
의약학 > 기초한의학
저자
송정빈 ( Jung Bin Song ) , 최진규 ( Jin Gyu Choi ) , 이동헌 ( Dong Hung Lee ) , ( Bhakta Prasad Gaire ) , 이창원 ( Chang Won Lee ) , 부영민 ( Young Min Bu ) , 최호영 ( Ho Young Choi ) , 김호철 ( Ho Cheol Kim )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2012년, 제27권 제6호, 71~76쪽(총6쪽)
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35301206.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: The purpose of this study was to evaluate the neuroprotective effect of Pueraria lobata extract on focal cerebral ischemia in mice. Methods: Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery using the intraluminal filament model. ICR male mice underwent 90 minutes of middle cerebral artery occlusion (MCAo) followed by 24 hours of reperfusion. Mice were administered Pueraria lobata extract orally at the dose of 300mg/kg just prior to reperfusion. Rotarod test and balance beam test were practiced to assess sensory-motor function 23 hours after MCAo. In rotarod test, the latency to fall on the accelerating rotarod was recorded for 5 min. In balance beam test, the score was graded according to number of slips and latency to cross. The infarct volume was measured 24 hours after MCAo using 2% 2,3,5-triphenyltetrazolium chloride (TTC) staining. Results: Pueraria lobata extract treated group showed significant reduction in infarct volume by 27.3% compared to control group ( p<0.05). In rotatod test, it also showed significant extension of latency time compared to control group (67.82±15.08 vs. 5.62±1.06, p<0.001). In contrast to performance in rotarod test, that in balance beam test did not improve with Pueraria lobata extract treatment. Conclusions: We conclude that Pueraria lobata extract has a significant neuroprotective effect and reduces damage of sensory-motor function in MCAo model. These findings suggest that Pueraria lobata could be a potent neuroprotective agent.
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