고과당식이 랫드모델에서 홍삼과 상엽 혼합투여에 의한 대사증후군 개선효과
분야
의약학 > 기초한의학
저자
이윤정 ( Yun Jung Lee ) , 김혜윰 ( Hye Yoom Kiim ) , 윤정주 ( Jung Joo Yoon ) , 이소민 ( So Min Lee ) , 안유미 ( You Mee Ahn ) , 고정현 ( Joung Hyun Kho ) , 고민철 ( Min Chul Kho ) , 이호섭 ( Ho Sub Lee ) , 최경민 ( Kyung Min Choi ) , 강대길 ( Dae Gill Kang )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2012년, 제27권 제6호, 99~105페이지(총7페이지)
파일형식
35301210.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: Korean red ginseng and Morus alba L, are used as a traditional treatment for diabetes, This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L, (MPM) ameliorates metabolic syndrome in fructose-fed rats, Methods: Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose (HF) diet alone for 8 weeks, with supplementation with MPM or rosiglitazone occurring during the final 6 weeks. Results: MPM and rosiglitazone, synthetic PPARγ agonist, treatment significantly prevented the increase in fasting serum glucose, leptin, triglyceride, and low density lipoprotein in the HF group when comparing with the control group. MPM and rosiglitazone also led to an increase in high density lipoprotein level in the HF group. The administration of MPM and rosiglitazone prevented the development of the metabolic disturbances such as impaired glucose tolerance, and blood pressure. MPM suppressed increased expressions of endothelin-1 (ET-1) in HF rat aorta. In addition, MPM significantly increased IR-β and PPAR-γ expression in muscle. Conclusions: Based on these results, we suggest that the administration of MPM improves metabolic syndrome through the alteration in lipid profiles and suppression of insulin resistant and blood pressure.
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