Long noncoding RNA involvement in cancer
자연과학 > 화학
( Reo Maruyama ) , ( Hiromu Suzuki )
생화학분자생물학회(구 한국생화학분자생물학회)
BMB Reports 2012년, 제45권 제11호, 604~611페이지(총8페이지)
02618143.pdf [무료 PDF 뷰어 다운로드]
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    Recent advances in genome and transcriptome analysis have enabled identification of numerous members of a new class of noncoding RNA, long noncoding RNA (lncRNA). lncRNAs are broadly defined as RNA molecules greater than 200 nt in length and lacking an open reading frame. Recent studies provide evidence that lncRNAs play central roles in a wide range of cellular processes through interaction with key component proteins in the gene regulatory system, and that alteration of their cell- or tissue-specific expression and/or their primary or secondary structures is thought to promote cell proliferation, invasion and metastasis. The biological and molecular characteristics of the large majority of lncRNAs remains unknown, and it is anticipated that improved understanding of the roles played by lncRNAs in cancer will lead to the development of novel biomarkers and effective therapeutic strategies.
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