Effects of chronic caloric restriction on kidney and heart redox status and antioxidant enzyme activities in Wistar rats
자연과학 > 화학
생화학분자생물학회(구 한국생화학분자생물학회)
BMB Reports 2012년, 제45권 제11호, 671~676쪽(총6쪽)
02618153.pdf [무료 PDF 뷰어 다운로드]
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    Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/ modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment; however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.
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