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의약학 > 내과학
저자
김인희 ( In Hee Kim )
발행기관
대한간학회
간행물정보
Postgraduate Courses (PG) 2012년, 제2012권 제1호, 91~99페이지(총9페이지)
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27405435.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Spontaneous bacterial peritonitis (SBP) is a spontaneous infection of ascitic fluid without an evident intra-abdominal, surgically treatable source of infection. SBP is common, recurrent complication of cirrhosis associated with poor outcome. The prevalence of SBP in hospitalized cirrhotic patients with ascites is 10-30%. Although mortality has been reduced to around 20-40% with early recognition of the disease and prompt and appropriate antibiotic therapy, it remains to be a major cause of mortality in patients with cirrhosis. Empirical antibiotic treatments are recommended immediately after the diagnosis of SBP, without the result of ascitic fluid culture. Since the most common causative organisms of SBP are Gram-negative aerobic bacteria, such as E. coli, the first line antibiotic treatment are third-generation cephalosporins. However, the proportion of microorganisms that are resistant to third generation cephalosporins and quinolones were increasing in cirrhotic patients with nosocomial SBP and these may be associated with treatment failure. The prophylactic antibiotics are recommended in patients with acute gastrointestinal hemorrhage, a previous history of SBP, low total protein content in ascitic fluid with advanced liver failure.
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