가토의 두정골 결손부 모델에서 수산화인회석에 4-hexylresorcinol을 혼합하여 만든 인공합성골이식재의 골형성효과에 대한 연구
분야
의약학 > 기초치의학
저자
김민근 ( Min Keun Kim ) , 박용태 ( Yong Tae Park ) , 김성곤 ( Seong Gon Kim ) , 박영욱 ( Young Wook Park ) , 이석근 ( Suk Keun Lee ) , 채원식 ( Weon Sik Choi )
발행기관
대한악안면성형재건외과학회
간행물정보
대한악안면성형재건외과학회지 2012년, 제34권 제6호, 377~383페이지(총7페이지)
파일형식
0s102248.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Purpose: The aim of this study was to evaluate the effect of 4-hexylresorcinol and hydroxyapatite combination graft on bone regeneration in the rabbit calvarial defect model. Methods: Ten New Zealand white rabbits were used for this study. Bilateral round shaped defects (diameter: 8.0 mm) were created on the parietal bone. 4-hexylresorcinol and hydroxyapatite combination graft material was grafted into the right parietal bone defect area (experimental). The left bone defect area was not filled with anything (control). The animals were sacrificed at 4 weeks and 8 weeks after grafting. A micro-computerized tomography of each specimen was taken, and the specimens were stained for histological analysis. Results: The average value of bone mineral density (BMD) and Bone volume (BV) was higher in the experimental group than in the control group at 4 weeks and 8 weeks after surgery. However, the difference was not statistically significant (P>0.05) at 8 weeks after grafting. The BMD and BV in the experimental group at 4 weeks after surgery was significantly higher than those in the control group (P <0.05). Conclusion: 4-hexylresorcinol and hydroxyapatite combination graft material showed higher initial bone formation than the control, however, there was no difference at 8weeks after operation.
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