가토 두개골 결손부에 이식된 저골(猪骨)과 혈소판 풍부 섬유소의 골형성 효과
분야
의약학 > 기초치의학
저자
박정익 ( Jong Ik Park ) , 전성배 ( Seong Bae Jeon ) , 송영일 ( Young Ii Song ) , 도형식 ( Hyung Sik Do ) , 어진용 ( Jin Yong Lee ) , 장현석 ( Hyun Seok Jang ) , 권종진 ( Jong Jin Kwon ) , 임재석 ( Jae Suk Rim ) , 이의석 ( Eui Seok Lee )
발행기관
대한악안면성형재건외과학회
간행물정보
대한악안면성형재건외과학회지 2012년, 제34권 제6호, 391~397페이지(총7페이지)
파일형식
0s102250.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Purpose: The purpose of this study was to evaluate the effectiveness of the platelet-rich fibrin (PRF) used in combination with the porcine cancellous bone as a scaffold, in promoting bone regeneration in the bone defects ofthe rabbit calvaria. Methods: Ten rabbits were used in the study. Three round-shaped defects (diameter 8.0 mm) were created in the rabbit calvaria and were filled with nothing (control group), porcine cancellousbone (Experimental Group 1, porcine bone) and PRF-mixed porcine cancellous bone (Experimental Group 2). TS-GBB is a xenogenic bone-substitute product comprised of a high heat-treated mineralized porcine cancellous bone. Animals were sacrificed at 6 weeks and 12 weeks for the histological and radiographic evaluations. Results: In the micro computed tomography and histological results, the experimental groups 1 and 2 showed more bone formation, remodeling, and calcification than the control group. The new bone formation ratio showed theGroup 2 to be larger than Group 1 at6 and 12 weeks. However, there was no significant difference between the experimental groups 1 and 2 in the new bone formation area, at the 6 and 12 weeks (P >0.05). Conclusion: The PRF-mixed group showed more bone formation than the porcine cancellousbonegroup (TS-GBB), butthere was a no significant difference. The PRF may not lead to enhanced bone healing when grafted with the porcine cancellous bone.
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