Research Papers : Cytochrome P-450 2A6 Inhibitor Based on the Indole Moiety
분야
공학 > 화학공학
저자
( Soo Lee ) , ( Hyang Yeol Lee )
발행기관
한국유화학회
간행물정보
한국유화학회지 2012년, 제29권 제3호, 435~442페이지(총8페이지)
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13001632.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The cytochrome P-450 enzymes (CYP 2A6) regulate many endogenous signaling molecules and drugs. Aryl alkynes such as 2-ethynylnaphthalene are important P450 inhibitors which have been extensively studied as medicines or as an effective chemical probes for profiling mouse liver microsomal P-450. Here we have synthesized indole-based novel P450 inhibitor, 5-ethynyl indole 3, and showed that it has successfully inhibited CYP 2A6 by chemical inhibition reaction. By using HPLC equipped with a photo diode array(PDA) detector, all of the peaks derived from the enzymatic reaction have been characterized.
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