Clinical Implications of Basic Research : Role of Janus Kinase/Signal Transducers and Activators of Transcription in the Pathogenesis of Pancreatitis and Pancreatic Cancer

분야: 의약학 > 내과학
저자: ( Ji Hoon Yu ) , ( Hye Young Kim )
발행기관: 대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보: Gut and Liver 2012년, 제6권 제4호, 417~422페이지(총6페이지)
파일형식: 19201835.pdf [무료 PDF 뷰어 다운로드]
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연관 논문

Review : Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis

Review : An Important Role of Nrf2-ARE Pathway in the Cellular Defense Mechanism

영문초록

In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal trans-ducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of cholecystokinin (CCK) have been reported in patients with acute pancreatitis, and treatment with cerulein, a CCK analogue, induces acute pancreatitis in a rodent model. Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trig-ger the phosphorylation of the JAK1, STAT1, and STAT3 pro-teins and induce the production of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in pancreatic acinar cells. The JAK/STAT pathway also stimu-lates cell proliferation and malignant transformation and inhibits apoptosis in the pancreas. This review discusses the possible role of the JAK/STAT pathway in the pathogenesis of pancreatitis and pancreatic cancer in response to oxidative stress. (Gut Liver 2012;6:417-422)

#JAK/STAT # Pancreatitis # Pancreatic cancer # Oxida-tive stress

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