Original Article : Characteristics of Hemorrhagic Peptic Ulcers in Patients Receiving Antithrombotic/Nonsteroidal Antiinflammatory
분야
의약학 > 내과학
저자
( Drug Therapy ) , ( Kazuhiko Nakamura ) , ( Kazuya Akahoshi ) , ( Toshiaki Ochiai ) , ( Keishi Komori ) , ( Kazuhiro Haraguchi ) , ( Munehiro Tanaka ) , ( Norimoto Nakamura ) , ( Yoshimasa Tanaka ) , ( Kana Kakigao ) , ( Haruei Ogino ) , ( Eikichi Ihara
발행기관
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보
Gut and Liver 2012년, 제6권 제4호, 423~426페이지(총4페이지)
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19201836.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background/Aims: Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. Methods: We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. Results: The patients in the AT group were significantly older than those in the C group (p<0.0001). The hemoglobin levels before/without transfusion were significantly lower in the AT group (8.24±2.41 g/dL) than in the C group (9.44±2.95 g/dL) (p<0.0001). After adjusting for age, the difference in the hemoglobin levels between the two groups remained significant (p=0.0334). The transfusion rates were significantly higher in the AT group than in the C group (p=0.0002). However, the outcome of endoscopic hemostasis was similar in the AT and C groups. Conclusions: Patients with hemorrhagic peptic ulcers receiving antithrombotic/NSAID therapies were exposed to a greater risk of severe bleeding that required transfusion but were still treatable by endoscopy. (Gut Liver 2012;6:423-426)
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