Original Article : Short and Long-Term Outcomes of Diabetes Mellitus in Patients with Autoimmune Pancreatitis after Steroid Therapy
분야
의약학 > 내과학
저자
( Yuji Miyamoto ) , ( Terumi Kamisawa ) , ( Taku Tabata ) , ( Seiichi Hara ) , ( Sawako Kuruma ) , ( Kazuro Chiba ) , ( Yoshihiko Inaba ) , ( Go Kuwata ) , ( Takashi Fujiwara ) , ( Hideto Egashira ) , ( Koichi Koizumi ) , ( Ryoko Sekiya ) , ( Junko Fujiwa
발행기관
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보
Gut and Liver 2012년, 제6권 제4호, 501~504페이지(총4페이지)
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19201849.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background/Aims: Autoimmune pancreatitis (AIP) is frequently associated with diabetes mellitus (DM). This study evaluated the effect of steroid therapy on the course of DM in AIP. Methods: Glucose tolerance was examined in 69 patients with AIP. DM onset was classified as either a simultaneous onset with AIP or an exacerbation of pre-existing DM. Based on the changes in the HbA1c levels and insulin dose, the responses of DM to steroids were classified as improved, no change, or worsened. Results: Thirty (46%) patients were diagnosed as having DM (simultaneous onset, n=17; pre-existing, n=13). Three months after starting the steroid treatment, the DM improved in 13 (54%) of 24 DM patients. The DM improved in 55%, had no change in 36%, and worsened in 9% of the 11 simultaneous onset DM patients, and it improved in 54%, had no change in 31%, and worsened in 15% of the 13 pre-existing DM patients. At approximately 3 years after starting the steroid treatment, the DM improved in 10 (63%) of 16 patients. The pancreatic exocrine function improved in parallel with the changes in the DM in seven patients. Conclusions: Because approximately 60% of DM associated with AIP is responsive to steroids in the short- and long-terms, marked DM associated with AIP appears to be an indication for steroid therapy. (Gut Liver 2012;6:501-504)
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