원저 : ABO 혈액형 부적합 성인 생체간이식 후 발생한 담도계 협착의 분석
분야
의약학 > 병리학
저자
윤영인 ( Young In Yoon ) , 송기원 ( Gi Won Song ) , 이승규 ( Sung Gyu Lee ) , 황신 ( Shin Hwang ) , 안철수 ( Chul Soo Ahn ) , 김기훈 ( Ki Hun Kim ) , 문덕복 ( Deok Bog Moon ) , 하태용 ( Tae Yong Ha ) , 정동환 ( Dong Hwan Jung ) , 박길춘 ( Gil Chun Park ) , 남궁정만 ( Jung Man Namgung ) ,
발행기관
대한이식학회
간행물정보
대한이식학회지 2012년, 제26권 제4호, 277~286페이지(총10페이지)
파일형식
17806281.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background: Despite recent improvements in survival outcome after ABO incompatible (ABOi) adult living donor liver transplantation (ALDLT), concerns about the incidence of biliary stricture (BS) still exist. However, reports on the actual incidence of BS have been scarce. Methods: From November 2008 to August 2011, 77 cases of ABOi ALDLTs have been performed. We compared patient and graft survival and BS-free survival rates (BSFSR) between these ABOi ALDLTs and 734 ABO compatible (ABOc) ALDLTs performed during the same period. We also analyzed characteristics of BS in ABOi ALDLT. Results: There was one mortality (1.3%) and one re-transplantation (due to small-for-size graft syndrome) among 77 cases of ABOi ALDLTs. Overall, 1-, 2-, and 3-year patient survival rates were 94.8%, comparable to ABOc ALDLTs (93.7%, 90.1%, 90.1%, P=0.20). BS occurred in 11 (13.8%) ABOi ALDLT patients. There were no significant differences in 1-, 2-, and 3-year BSFSR between ABOi and ABOc ALDLT patients (87.5% vs. 88.1%, 83.4% vs. 87.5%, and 83.4% vs. 86.4%, P=0.55). Among 10 patients with BS, four patients showed diffuse multiple intrahepatic strictures, which were linked to the death of two patients. Conclusions: The survival outcome of ABOi ALDLT is comparable to ABOc ALDLT. The incidence of BS of ABOi ALDLT was not superior to that of ABOc ALDLT. However, ABO incompatibility is related to the development of diffuse multiple intrahepatic BSs (rarely seen in ABOc ALDLT) and can cause graft failure and patient death.
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