종설 : 알레르기질환에서의 Type 2 Innate Lymphoid Cell의 역할
분야
의약학 > 내과학
저자
모지훈 ( Ji Hun Mo )
발행기관
대한천식알레르기학회(구 대한알레르기학회)
간행물정보
천식 및 알레르기 2012년, 제32권 제4호, 207~212페이지(총6페이지)
파일형식
18103569.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORγt innate lymphoid cell, type 2 innate lymphoid cells and natual killer cells. Among them, type 2 innate lymphoid cells plays an important role in type 2 immunity by releasing type 2 cytokines, such as interleukin-5 and interleukin- 13, and makes a match for Th2 cell of the adaptive immune system. Type 2 innate lymphoid cells responses are initiated by interleukin-25 and interleukin-33, which are produced by several cell types, such as epithelial cells, tissue macrophages and dendritic cells. These cytokines strongly activate type 2 innate lymphoid cells, leading to the production of type 2 cytokines, including, interleukin-5 and interleukin- 13. In this review, we will discuss the characteristics and development of type 2 innate lymphoid cells and the role of type 2 innate lymphoid cells in allergic diseases in detail.
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