Original Articles : Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis; a multicenter retrospective study in Korea
분야
의약학 > 내과학
저자
( Jin Nyoung Kim ) , ( Kyoung Min Sohn ) , ( Moon Young Kim ) , ( Ki Tae Suk ) , ( Soung Won Jeong ) , ( Ho Eun Jung ) , ( Sae Hwan Lee ) , ( Sang Gyune Kim ) , ( Jae Young Jang ) , ( Young Seok Kim ) , ( Soon Koo Baik ) , ( Hong Soo Kim ) , ( Dong Joon K
발행기관
대한간학회
간행물정보
Clinical and Molecular Hepatology(대한간학회지) 2012년, 제18권 제4호, 391~396페이지(총6페이지)
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    영문초록
    Background/Aims: Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined. Methods: Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices. Results: The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%. Conclusions: The HVPG was higher in patients with first variceal hemorrhage than in those without it. (Clin Mol Hepatol 2012;18:391-396)
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